The Effctiveness Of A Inhaler

Healthcare Stock Watch: MNKD, KERX, CYTR, ONTY, TTNP

MNKD:  Mannkind Corporation (NASDAQ:MNKD) has been hammered all year long after receiving  another denial  from the FDA in January for the approval of the company’s inhaled insulin product, Afrezza. Solid back-up news was slow to materialize and shares slipped into the $2 range with the latest round of market turmoil.

The FDA’s concerns that led to the Afrezza denial stemmed from the effectiveness of Mannkind’s next-generation Afrezza inhaler, which was different than the one used in the Phase III trials, and it was new trials with the new inhaler that the FDA wanted to see before finalizing its approval decision.

Shares reached the three dollar mark again, however, when the company  announced  late last week that it had confirmed the trial design with the FDA of two upcoming clinical trials that will test Afrezza with the next-generation inhaler.

In turn, JMP Securities  upgraded  MNKD to ‘Mkt Outperform’ and slapped a $7 price tag on the stock, enough of a mention to draw in new investor interest that could put the stock on the path to a rebound as the trials develop.

Life’s not all fine and dandy just yet, however, as funding could still be an issue and Afrezza will again need to get through the FDA – and the FDA has given no indications over the past few years that it is ready to accept any other form of insulin delivery outside of the needle.

The FDA nod on the trial design is good news for Mannkind, which could start moving higher.

Stay tuned.

KERX:  Shares of Keryx Biopharmaceuticals (NASDAQ:KERX) have been on the fly since  hitting lows  of right around three bucks last week, and a close of over four dollars on Monday is a pretty good indicator that investors have not forgotten about the potential of the company’s two Phase III products, Zerenex for kidney disease and Perifisone as an anti-cancer agent.

Chest Infection, Asthma, and Allergies - Do I Really Need to See a ...

Pneumonia is the infective, inflammatory or obstructive process of the filling with anything such as fluid, pus, mucus, bacteria, or pollen of the millions of tiny microscopic air baggies (sacs.) The sacs (alveoli) are located at the tips of these and become smaller and smaller until they are small tubes of the respiratory tubal system. These tubes are used to transport air and the sacs are used for the diffusion of oxygen into the bloodstream. It is the circulation and transfer of carbon dioxide back into the sacs out of the bloodstream and respiration out of the body. Asthma is an over-sensitive airway disease. Asthma is a response of hyperactivity and hypersensitivity inflammation, swelling, hyper-mucus secretion, muscular constriction of the air carrying bronchial tubes. This stops transfer of gases to the alveolar sacs into the bloodstream. It is the closure of the inside opening of the tube from swelling and constriction bronchial tubes and respiration to the alveoli sacs. It is the closure of the inside opening of the tube from swelling and constriction of the muscle in the tube wall. Excessive, very thick mucus production from the inside lining of the tube causes partial occlusion, wheezing sounds, or total occlusion of the breathing passageway system of the lungs. It is caused by inflammation and constriction of the bronchiole tubes. You must specifically fix the chronic problem instead of treating the acute symptoms for only immediate relief. Profiles testing show many various types of allergies when and where they appear. Allergy can be sore throat, headache, fatigue, pneumonia, and many other symptoms. A Mast Cell, Basophile and Eosinophil are the body’s natural responses to defend from the stimulus of allergens or infection. These natural bodies produce chemical called histamine. When histamine is released it reacts like an acid to help fight infections and kill or defend the stimulus. Now in the 21st century with recent advantages with medical care you can do more of the things you need to do in your daily life. Enjoy living comfortable and mostly symptom free with ease of breathing, and get your energy and health back. It is a 365-day serious and significantly increasing health problem. With many flare-ups, there is still more mucus production, constriction, and swelling of the bronchial tubes in the lungs than a normal person. You must learn what triggers your asthma and how to avoid them. Prevention can involve anti-inflammatory medication and specific treatment of the problem and not just the apparent seen or felt symptoms. Eating oranges, fish, crab, shrimp, or exposure to grasses, mold and animal dander can all cause respiratory asthma/bronchitis symptoms. A bronchodilating inhaler is a temporary medicine that works by relaxing the tubular muscle constriction and opens the air tubes of bronchioles. You get immediate relief. It does not get rid of the mucus in the lungs or the stimulus causing the constriction. It is only for temporary and fast relief. This is a great medication when correctly used. Again, this is a temporary relief medication. This should not be used as a long-term treatment. If you use your bronchodilator more than 10 times a day, it is a true sign of trouble. One good thing to have around is the Peak Flow Meter- this is your best at home indicator for you and your doctor to measure the air speed and flow from your lips. This tool is designed specifically to measure your respiratory and lung function. The peak flow measures the maximum air velocity at your lips versus your height and age. Weight and other factors will have no effect on this measurement. A spacer decreases the coordination necessary for medication delivery and effectiveness used for inhalers. It prevents the wasting of money and medicine in the back of your throat. It can avoid unnecessary side effects of sore throat or throat ulcers from the medicine. The cold “Freon effect” often stops people inhaling the medicine. Therefore, most of the medicine goes to the back of the throat. At least eighty percent (80%) of the medication used from a regular inhaler is wasted. A spacer increases the effectiveness and use of the medications and decreases costs by ten times. Asthma is the excessive mucus thickening, mucus plugging, and tightly constricted mucosal airways. The spacer dissipates the medicine into the air to be more easily inhaled. More than fifty percent (50%) of people have poor inhaler technique and fifty percent regress in technique within one month of starting the use of medications. Corticosteroids that are used for asthma control are not the same as anabolic steroids used by athletes for abuse. Many months of steroids can cause weight gain, upset stomach, stomach ulcers, and the thinning of the bones. Too few steroids can cause hospitalization, death, and mood changes. Corticosteroid inhalers are the best consistent daily prevention therapy. Steroids appropriately used are essential for exacerbations and must be carefully, consistently, and closely monitored by a physician. Asthma is an excessive inflammation, over-reactive, and over-sensitivity of the lungs to stimulus with the production thick mucus and mucus plugging. Specific anti-inflammatory medications are a treatment. If left untreated, this will lead to permanent lung function loss. If silently you lose 2% of your lung function a year for 10 years, you have lost approximately one-third (1/3rd) of your lung function. Asthma anti-inflammatory choices are: Inhaled corticosteroids, leukotriene blockers, cromolyn, and others. Side effects of these medications must be carefully and consistently balanced with view to permanent lung damage and disability. Routine checkups are essential. All allergy patients should be seen at least every 2-3 months– and immediately if severe reaction, infection, or more than a minimal problem arises. There must be careful attention to triggers. Infections such as sinus infections can and often do cause poor control of asthma. Cigarette smoke (even passive and 2nd hand smoke), dust mite feces are all triggers. A typical mattress has more than 200,000 living dust mites. Animal dander is another trigger–keep pets out of the bedroom. Pollen and mold humidifiers can increase mold. Cockroach parts and feces when they dry turn into a powder, causing a possible trigger for asthma. Aspirin and ibuprofen: About 10% of people with asthma are sensitive to aspirin and ibuprofen compounds. Sulfates on food preservatives for fruits, grapes, cherries, wine and beer, as well as cold air and exercise are all triggers. Each year, about 5,000 people die of asthma. The majority of these people did not have severe disease. When using inhalers, you exhale all the air in your lungs, use a spacer, inhale the medicine, hold your breath for 10 seconds, breath out, and repeat. The Nebulizer machine delivers therapy for five to ten minutes and is much more powerful as an immediate rescue inhaler. Prevention of flu and pneumococcal vaccines is essential. Allergy testing and/or injections, antibiotics and antivirals, are very important aids in the maintenance of these complex problems, potential complications, and the quality of life. Douglas Beatty M.D.

A Christmas carol in prose, being a ghost story of Christmas

Of mice and men

The Hitchhiker's Guide to the Galaxy

The Help

The kite runner